Two sample MR report
THBS1_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | 0.0605393 | 0.0728154 | 0.4155593 |
| Weighted median | 22 | -0.0276563 | 0.0064579 | 0.0000185 |
| Inverse variance weighted | 22 | -0.0177646 | 0.0048516 | 0.0002506 |
| Simple mode | 22 | -0.0339061 | 0.0131892 | 0.0178197 |
| Weighted mode | 22 | -0.0333562 | 0.0130401 | 0.0183231 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 21.63072 | 20 | 0.3608800 |
| Inverse variance weighted | 22.88698 | 21 | 0.3500338 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0434694 | 0.0403334 | 0.2939723 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004333 | 0 | TRUE | 0.0485453 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
